The Arizona Cardinals offense has struggled through four weeks. Head coach Jonathan Gannon suggested that tweaks could be coming after their mini-bye.

The Cardinals were threatening to take the lead back when Harrison Jr. bobbled a perfect Murray pass on third and 11, and the ball landed right in the arms of Seahawks linebacker Ernest Jones IV. The 2024 No. 4 overall pick had a big drop last week, too.

The primetime lights were too bright for Jonathan Gannon's squad in their 23-20 loss in Week 4. The Cardinals are now 2-2 on the season with both losses coming within the NFC West.

What was the Seattle Seahawks vs Arizona Cardinals score? Look back at Thursday Night Football score updates from NFL Week 4 game on Sept. 25, 2025.

Seattle avoided a major collapse once Jason Myers drilled a 52-yard field goal with no time left in regulation to escape the desert with a 23-20 victory, moving to 3-1 on the season and staying in position to compete for the division title. Despite the late rally, the Cardinals fall to 2-2 after winning their first two games to start the year.

On the first, Murray was dropped for a loss of seven on first-and-goal from the 9-yard line. On the next play, wide receiver Marvin Harrison Jr. high-pointed a pass in the end zone with cornerback Devon Witherspoon all over him and maintained control to the ground for a touchdown.

The Seattle Seahawks kicked a field goal as time expired to stave off a spirited fourth-quarter comeback from the Arizona Cardinals on Thursday Night Football.

Kenneth Walker III’s historical stats vs. the Cardinals show consistent fantasy success, making him a strong RB2 play in Week 4’s Thursday Night Football matchup.