Philip Rivers and the Indianapolis Colts take on the San Francisco 49ers for Monday Night Football at Lucas Oil Stadium.

Preview the Indianapolis Colts' NFL Week 15 matchup with the Seahawks, including live stream, TV channel, odds, and game information.

The Indianapolis Colts visit the Seattle Seahawks in NFL Week 15 action today, Dec. 14, 2025. Inactives, injury report, who's in, who's out.

Preview the Seattle Seahawks' NFL Week 15 matchup with the Colts, including live stream, TV channel, odds, and game information.

The Indianapolis Colts competed, fought, and clawed to pull off the improbable against the Seattle Seahawks, but ultimately fell short, 18-16. After signing Philip Rivers to lead the squad, many believed this would be a disaster - I was essentially one of those people.

Seahawks head coach Mike Macdonald gave credit to Director of Football Analysis and Special Situations, Brian Eayrs, as the unsung hero.

Seattle is a massive home favorite, given that the Colts will be starting a 44-year-old coming off the couch. Indianapolis wins in just 21% of the model's simulations, which offers notable value for the +700 Colts money line. Indy covers the big spread in 56% of the sims and the Over hits 59% of the time.

The Indianapolis Colts and Philip Rivers have an uphill battle against the Seattle Seahawks, but anything can happen.