The NFL released its full 272-game schedule Wednesday. Here's a look at the most interesting matchup in each of the 18 weeks.

Iyer picked the top game for all 32 teams' 2025 schedule and wrote that the Rams' matchups against the Detroit Lions in Week 15, the San Francisco 49ers in Weeks 5 and 10, and Atlanta Falcons in Week 17 will be those respective club's best games of their individual seasons.

That said, we got our NFL fix on Wednesday night as the league unveiled the 2025 regular-season schedule. While we knew every team's opponent for this upcoming season, we can now sink our teeth into the logistics of the entire year,

The NFL announced team-by-team opponents and select prime-time games for the 2025 preseason on Wednesday.

The 49ers endured a disappointing 2024 NFL season, but it has set them up for potential success in 2025. San Francisco is playing a fourth-place schedule after finishing last in the NFC West. That set them up with matchups against the Bears, Browns and Giants.

Here's an entire listing of the Monday night schedule. Each game can be seen on ESPN (unless noted otherwise), with select matchups also being shown on the "ManningCast," which is aired on ESPN2 and on ESPN+. We've also included a ranking of the entire "Monday Night Football" schedule.

Only four teams have a bigger rest advantage over their opponents than the Rams in 2025, which is great news for LA

Coach Brian Daboll better get a win here. The QB-desperate Saints are going to be awful in 2025. Big Blue will be plenty battle-tested before this matchup, facing the Commanders, Cowboys, Chiefs and Chargers leading up to it.

The Atlanta Falcons are likely to have several key December games during the 2025 NFL regular season. The 2025 NFL schedule is finally here. Atlanta Falcons fans will be happy to hear that their team will play five primetime games and a Sunday morning contest from Europe.

By now every fan has probably studied their team’s schedule for 2025 from start to finish. After all, the schedule release is a big day on the NFL calendar. But when does every other team play and what are their matchups?