San Francisco 49ers running back Christian McCaffrey, the NFL's leader in yards from scrimmage, could be in line to lay the wood on his former team, the Carolina Panthers, on Monday night.

Throughout the 2025 NFL season, the San Francisco 49ers have traveled to all corners of the United States. From divisional battles across California, they’ve headed east to New York, down to Florida to face the Tampa Bay Buccaneers, and into Texas for a matchup with DeMeco Ryans’ Houston Texans.

49ers head coach Kyle Shanahan employs an offensive system that tends to get the most out of his players, especially his quarterbacks. It has played a role in Jones' apparent revival, and perhaps O'Connell, who was named second-team All-Big-Ten twice while at Purdue University, can be a nice insurance option for them in 2026.

The San Francisco 49ers will take on the Carolina Panthers on Monday, but they'll be without two players and could have two more miss the game.

Georgia opted for a run-heavy approach in its final tuneup before a showdown against Georgia Tech, and the Charlotte 49ers couldn’t keep up.

El receptor lesionado de los 49ers de San Francisco Brandon Aiyuk vio anulados aproximadamente 27 millones de dólares en dinero prácticamente garantizado en su contrato para el próximo año, en lo que

Pineiro has a grade 1 hamstring strain and is considered “week-to-week.” The 49ers signed Matt Gay to the practice squad earlier this week, and he will kick against the Panthers on Monday night. Bethune has a high-ankle sprain and is expected to miss multiple weeks but will not go on injured reserve with the team’s off week in Week 14.

The 49ers will be without record-setting kicker Eddy Piñeiro against the Panthers, as San Francisco rules him out for Monday Night Football.