The San Francisco 49ers are trending the right way from a health perspective entering a Week 16 showdown with the ...

The 49ers can clinch a playoff berth in Week 16 with a win over the Colts — or with help before kickoff. Here's how San ...

An ESPN analyst believes the 49ers can make noise in the playoffs, but one fatal flaw could derail San Francisco's postseason ...

San Francisco 49ers head coach Kyle Shanahan discussed QB Brock Purdy's standout performance, reflected on key moments from ...

The 49ers need one domino to fall and the ball is in the court for the top seed in the NFC.

Kyle Shanahan made an admission about the 49ers' lack of interactions with Brandon Aiyuk following their win over the Titans ...

San Francisco 49ers quarterback Brock Purdy looked like a basketball player with an impressive touchdown pass on Sunday.

The San Francisco 49ers announced an update on running back Christian McCaffrey.

A 10-4 record keeps the 49ers in the thick of a wild NFC playoff race and moved their win streak to four games. The Titans ...

Bhanpuri notes that the 49ers have a 90% chance of making the playoffs entering Week 15. A win over the Titans would raise ...

The San Francisco 49ers hosted a halftime ceremony this Sunday to celebrate the induction of three-time Super Bowl champion Brent Jones into the Edward J. DeBartolo Sr. San Francisco 49ers Hall of ...

NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers ...