The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

USA Today's NFL experts make their picks for a Week 11 showdown between the Arizona Cardinals and San Francisco 49ers

Now the San Francisco 49ers look like a team that might be peaking at the right time. Purdy threw three touchdown passes, Christian McCaffrey had two rushing touchdowns and a receiving score, and the 49ers beat the sloppy Arizona Cardinals 41-22 on Sunday.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

The two AFC West squads will face off in the desert on Sunday afternoon. After six weeks of dealing with turf toe, San Francisco 49ers quarterback Brock Purdy will be back in action on Sunday, Nov. 16 as his team travels to take on the Arizona Cardinals.

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the team’s fourth win in a row.

Learn which TV channel or how to live stream the NFL Week 15 San Francisco 49ers and Tennessee Titans game, Sunday, Dec. 14.

"We're positioned right where we want to be," George Kittle said after the 49ers' 41-22 win over the Cardinals. "Our offense is basically healthy." Mike Christy / Getty Images Arizona Cardinals quarterback Jacoby Brissett finished Sunday’s game with 452 ...

The Niners are coming off a win over the Arizona Cardinals in which the offense looked full-strength with Brock Purdy and Ricky Pearsall back as Christian McCaffrey shone as a receiver.

This is a great NFL matchup that you will not want to miss; make sure to tune in and catch all the action. Fubo offers a free trial, and you can watch the NFL on local CBS and FOX broadcasts every Sunday. You can also live stream NFL RedZone and catch football all season long on CBS, FOX, ESPN, NFL Network, and more.