The Na⁺/K⁺-ATPase is a ubiquitous P-type ion pump that actively exports three sodium ions in exchange for two potassium ions per ATP hydrolysed, thereby maintaining electrochemical gradients essential ...

Vacuolar ATPases (V-ATPases) are rotary, multi-subunit proton pumps that harness the energy of ATP hydrolysis to acidify intracellular compartments and, in specialised cells, the extracellular milieu.

Targeting Na+/K+ ATPase alpha 1 (ATP1A1) subunit proteins could help identify novel therapies for addressing blood clots and thrombosis, according to a new study by Marshall University researchers.

Nagoya University-centered researchers first in world to determine crystal structure of gastric proton pump responsible for gastric acid secretion "In our study, we used X-ray crystallography to ...

The rap sheet for β-CTF is growing longer. The C-terminal fragment, produced when β-secretase cleaves APP, binds to—and blocks assembly of—vacuolar ATPase, a proton pump that fuels acidification of ...

The gastric proton pump plays a central role in regulating stomach acidity, enabling both efficient digestion and protection against ingested pathogens. This membrane-embedded enzyme, also known as ...

One of the cell's key enzymes, the calcium pump, has now been been described in its decisive moment -- a so-called transition state. These findings provide a very detailed picture of how one of the ...

To pump the hydrogen ions into the stomach, the protein first needs to bind to a potassium ion (K +). Similar proteins typically bind two such potassium ions to trigger the pump mechanism. But H + /K ...

The gastric proton pump, also known as H+,K+-ATPase, is expressed on the surface of the stomach to secrete the gastric acid indispensable for digestion of proteins in food. However, too much acid ...

Nagoya University researchers and colleagues have improved understanding of the molecular mechanisms of a key protein that makes the stomach acidic. Their findings, published in the journal Nature ...