Monoclonal antibodies (mAbs) contain N-linked glycans that influence pharmacokinetics and efficacy, making glycoform ...

The ability to modulate high-mannose glycans during the production and reformulation of monoclonal antibodies (mAbs), antibody-drug conjugates, and biosimilars is an important factor affecting ...

Monoclonal antibodies are highly specific for their antigen and have a well-characterized structure, making them ideal for use as antibody therapeutics. 5 Each mAb, composed of two heavy and two light ...

Japanese researchers investigated how polyamines affect the functional profile of monoclonal antibodies and their production from CHO cells, and found that spermidine supplementation contributes to ...

Producers of biopharmaceuticals are finding that the assessment of critical quality attributes is increasingly a matter of evaluating post-translational modifications (PTMs), especially glycosylation.

Francesca has an MSci in Biochemistry from the University of Birmingham.View full profile Francesca has an MSci in Biochemistry from the University of Birmingham. The rest of this article is behind a ...

Over 1.8 million infections and over 118 thousand deaths have resulted from the emergence of SARS-CoV-2 and this number is still growing. SARS-CoV-2 is similar to SARS-CoV and MERS-CoV. It is highly ...

A comprehensive study mapped the dynamic glycosylation landscape of rat serum proteins, uncovering sex- and time-dependent ...

Singapore’s drug discovery efforts reached a new milestone as EBC-129, the first made-in-Singapore antibody-drug conjugate, was cleared by the US FDA to progress into first-in-human studies. As an ...

In a recent study posted to the bioRxiv* preprint server, researchers explored the differences in infant and maternal cord antibody functions between severe acute respiratory syndrome coronavirus 2 ...