Zolpidem is a non-benzodiazepine agonist at benzodiazepine binding site in GABA A receptors, which is increasingly prescribed. Recent studies suggest that prolonged zolpidem treatment induces ...

Using cryo-electron microscopy, scientists have gotten their first atomic snapshot of a human GABA A receptor. This inhibitory channel is the target of a range of anesthetic, anxiolytic, and ...

Benzodiazepines exert rapid anxiolytic effects by increasing GABA (γ-aminobutyric acid)-mediated neurotransmission. However, their use in treating anxiety disorders is limited owing to the loss of ...

People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for ...

People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for ...

SOUTH SAN FRANCISCO, Calif., March 11, 2021 (GLOBE NEWSWIRE) -- VistaGen Therapeutics, Inc. (NASDAQ: VTGN), a biopharmaceutical company committed to developing and commercializing a new generation of ...

Researchers have found that a naturally occurring protein secreted only in discrete areas of the mammalian brain may act as a Valium-like brake on certain types of epileptic seizures. Researchers at ...

Flunitrazepam, a potent benzodiazepine, reversibly binds to the benzodiazepine receptor with high affinity. When irradiated with UV light, flunitrazepam was irreversibly linked to brain tissue.

Abstract: We investigated in this study the pharmacological properties of AC-3933 [5-(3-methoxyphenyl)-3-(5-methyl-1, 2, 4-oxadiazol-3-yl)-1, 6-naphthyridin-2(1H)-one], a novel benzodiazepine receptor ...