The Detroit Lions will be the first opponent to square off against the Buffalo Bills in brand new Highmark Stadium.

The Buffalo Bills will host the Detroit Lions in the first game at Buffalo's new Highmark Stadium. Here's when: ...

Is a Week 2 Bills vs Lions matchup a potential Super Bowl preview?

Josh Allen and Buffalo will host Detroit at Highmark Stadium on Sept. 17, this year's first TNF game. Megan Briggs / Getty Images The Buffalo Bills will open their new stadium with a “Thursday Night ...

As the 2026 NFL season approaches, the Week 2 "Thursday Night Football" clash on Sept. 17 between the Detroit Lions and ...

ROCHESTER, N.Y. (WROC) — We’ve learned the date of the home opener at the Bills new Highmark Stadium. Love it or hate it, the Bills will host the Lions on Thursday, September 17 at 8:15 p.m. NFL ...

The Buffalo Bills are getting a prime opportunity to show off their new stadium early in the 2026 season – in more ways than one. The Bills will host the Detroit Lions in primetime on Amazon Prime ...