The pathological hallmark of Alzheimer’s disease (AD) is accumulation of misfolded amyloid-β peptides and hyperphosphorylated tau protein in the brain. Increasing evidence suggests that ...

The enzyme caspase-8 regulates different modes of cell death, according to new research. The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

Expression profiles associated with disease progression in non-small cell lung cancer. Background: Cisplatin is a platinum-based chemotherapeutic drug used for treating a variety of human cancers such ...

Researchers have revealed insights into the mechanism of how coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV exploit a host protease called 'cysteine-aspartic protease 6' (caspase-6) for ...

A new study offers important mechanistic insights into a recently discovered CRISPR-guided caspase, or Craspase. Using cryo-electron microscopy (cryo-EM), researchers explained its target RNA cleavage ...

A new preclinical study from Weill Cornell Medicine found that the protein caspase-5 (CASP5), long thought to be a foot soldier in the body's defense against bacterial infection, does not actually ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of ...

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice ...

SAN DIEGO, March 16, 2023 (GLOBE NEWSWIRE) -- Histogen Inc. (NASDAQ: HSTO), a clinical-stage therapeutics company on developing potential first-in-class clinical and preclinical small molecule ...