A new study from Washington University School of Medicine in St. Louis identifies a possible way to slow or block progression of age-related macular degeneration, a leading cause of blindness in ...

An experimental gene-editing therapy that aims to lower bad cholesterol for the long-term after a single infusion is off to a ...

Cholesterol metabolism extends beyond its well-established role in membrane structure and steroidogenesis to become a pivotal regulator of immune function. Endogenous synthesis in the endoplasmic ...

Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

Cholesterol biosynthesis disorders encompass a group of inborn errors and pharmacologically induced perturbations affecting the multistep metabolic cascade that generates cholesterol from acetyl-CoA.

Since then, many scientists, including Lu, who now leads his own research group at Western University, have shown that PIN1 is overexpressed in different types of cancer and regulates many oncogenes ...

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson’s disease in mice. Published in the open ...