Accurate duplication of the genome is fundamental to cellular viability and prevention of disease. Replicative DNA polymerases achieve high fidelity through three interconnected mechanisms: intrinsic ...
Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
Viral replication relies fundamentally on specialised DNA polymerases that orchestrate genome synthesis, fidelity control and interaction with viral and host factors. These enzymes exhibit remarkable ...
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