Nature

Protracted infusional 5-fluorouracil plus high-dose folinic acid combined with bolus mitomycin C in patients with gastrointestinal cancer: a phase I/II dose escalation study

Mitomycin C (MMC) is a quinone-containing antitumour antibiotic that is reductively activated by a variety of enzymatic systems to metabolites that alkylate and crosslink DNA (Dorr, 1988). The ...
Nature

Mitomycin C and Vinorelbine for second-line chemotherapy in NSCLC – a phase II trial

Single-agent therapy with Docetaxel or Pemetrexed is the current therapy of choice for second-line treatment in advanced non-small-cell lung cancer (NSCLC). The role of older agents was underattended ...
National Institute for Health and Care Excellence

Quality statement 2: Chemotherapy during transurethral resection of bladder tumour

Adults with suspected bladder cancer are offered a single dose of intravesical mitomycin C, given at the same time as the first transurethral resection of bladder tumour (TURBT). A single dose of ...