Offense Ranking: 21st Defense Ranking: 5th Strength of Schedule: 2nd. Through the first four games of the 2025 season, LSU is

No. 4 LSU will hit the road to Oxford on Friday for the program's Week 5 SEC clash against Lane Kifin and the Ole Miss Rebels at Vaught Hemingway Stadium. After

The complexion of Saturday's showdown between No. 4 LSU and No. 13 Ole Miss looks far different than originally anticipated, thanks to an unexpected quarterback development for the Rebels. Division II transfer Trinidad Chambliss has burst onto the scene for Ole Miss amid the injury-related absence of starter Austin Simmons.

Preview the Sept. 27 matchup between the Ole Miss Rebels and LSU Tigers with predictions, odds, over/under, spread, betting lines and more.

Saturday in Oxford is shaping up to be one of those afternoons you’ll tell your grandkids about — LSU Tigers (4-0) and Ole Miss (4-0), both undefeated, colliding at 3:30 p.m.

Brian Kelly will keep things under control as the Tigers tame the Rebels on the road, per our LSU vs. Mississippi predictions for Saturday, September 27, 2025.

Jackson's Week 5 college football predictions for all ranked games and top-25 matchups. His picks for Alabama vs. Georgia, LSU vs. Ole Miss, and more.

These are two of the big questions that loom over Saturday night's game between No. 17 Alabama and No. 5 Georgia. Alabama already has one loss from its season opener against Florida State and would love to start its challenging SEC slate with a win.

LSU believed it had one of the quarterbacks that would define the 2025 season, but so far the Tigers have been more about their defense than about Garrett Nussmeier. Their offense ranks No. 60 in expected points added (EPA) per snap, far from a threat.