Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. Damage to this layer - lysosomal membrane ...

Lysosomes are thought of as cellular organelles that play an important role in recycling proteins and maintaning cells by breaking down stuff that isn’t needed. But new research has found that ...

A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new ...

Macrophages are the specialized phagocytic cells that respond to toxic particle depositions to exert inflammatory and clearance responses. These long-lived immune cells engulf foreign substances like ...

Mitochondria generate most of the cell’s energy. However, when they become dysfunctional, damaged, or old, mitochondria can turn into pro-death organelles, which produce reactive oxygen species that ...