The San Francisco 49ers (6-4) visit the Arizona Cardinals (3-6) on Sunday at 4:05 p.m. ET, in a battle featuring two excellent pass-catchers in Christian McCaffrey and Trey McBride.

The Jacksonville Jaguars (6-4) are considered favorites (-2.5) according to the point spread ahead of their game against the Arizona Cardinals (3-7) on November 23, 2025, starting at 4:05 p.m. ET, air...