A new hypothesis article was published in Oncotarget (Volume 17) on January 3, 2026, titled “Hypothesis: HPV E6 and COVID ...
The protein p53, best known as the "guardian of the genome" for its role in preventing cancer, can affect blood vessels in ...
Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...
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Resistance to rezatapopt: New TP53 mutations identified in cancer patients
Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden discussed the unique mutational spectrum of the transformation-related ...
TP53 mutations are crucial in cancer development and treatment response, influenced by genetic and environmental factors. In CLL and AML, TP53 serves as a significant prognostic marker, affecting ...
The protein p53, best known as the "guardian of the genome" for its role in preventing cancer, can affect blood vessels in ...
Frontier Medicines Corp. has announced the selection of FMC-220, a first-in-class covalent small-molecule activator of p53 Y220C designed to address potency and tolerability challenges of noncovalent ...
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