The NMR and Drug Metabolism Core has developed rapid and efficient approaches to investigate metabolism, metabolic stability, pharmacokinetics (PK), and chemical structure identification of small ...
Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...
Proteasome Inhibition With Bortezomib (PS-341): A Phase I Study With Pharmacodynamic End Points Using a Day 1 and Day 4 Schedule in a 14-Day Cycle These data suggest that pretreatment evaluation of ...
Severe visual illnesses are increasing in our society, and effective treatments are missing for diseases as age-related macular degeneration, diabetic retinopathy, and glaucoma. Both industry and ...
One of the most comprehensive ocular pharmacokinetic studies including metabolism so far provides valuable information for ocular drug development. Severe visual illnesses are increasing in our ...
A quote from Rudolph Buchheim, an experimental pharmacologist who lived from 1820 to 1879, summarizes the nature and importance of studies in drug metabolism, including the pharmacokinetics and ...
Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration. Paclitaxel pharmacokinetics were studied in 55 courses of therapy in 30 patients. Paclitaxel ...
Starting in 2010, Springer will publish the European Journal of Drug Metabolism and Pharmacokinetics. All aspects of drug delivery and bioavailability are covered in the journal, which was previously ...
A new in vivo pharmacokinetic recall study involving 114 participants in the Estonian Biobank has provided the first clinical ...
Figure 1: Overview and workflow used in this study. Figure 3: Analysis of MetChange analysis of matched transcriptomic/metabolomics data in S. cerevisiae under carbon ...
Severe visual illnesses are increasing in our society, and effective treatments are missing for diseases as age-related macular degeneration, diabetic retinopathy, and glaucoma. Both industry and ...
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