Incorporating a polygenic risk score into prostate cancer screening could enhance the detection of clinically significant prostate cancer that conventional screening may miss, according to results of ...

Using polygenic risk scores along with positive family histories and breast cancer-associated gene mutations improves risk stratification for breast cancer screening. Compared with a lower polygenic ...

As predictive medicine advances, legal scholars warn that decades-old federal guidelines could set up a potential clash between your genes and your job.

According to a research letter published in JAMA Internal Medicine, prostate cancer screening frequently results in biopsies that find clinically insignificant cancer or no cancer at all. A polygenic ...

Please provide your email address to receive an email when new articles are posted on . A polygenic risk score that includes rare variants did not substantially improve osteoporosis or fracture risk ...

Polygenic risk scores, which estimate a person's disease risk based on thousands or millions of common genetic variants, perform poorly in screening and prediction of common diseases such as heart ...

Considerable progress has been made in uncovering common single nucleotide variants and developing mechanisms for genomic profiling. Using this knowledge routinely as part of clinical and public ...

Please provide your email address to receive an email when new articles are posted on . In a head-to-head comparison, coronary artery calcium score improved CV risk discrimination and a polygenic risk ...

The optimism is not unfounded. In specific, well-defined clinical scenarios, polygenic scores are beginning to demonstrate some tangible utility. For cardiovascular disease, MI-GENES, a 10-year follow ...