The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

A SLAC-Stanford study revealed four intermediate steps in folding a human protein called tubulin, all directed by the inner walls of a cellular machine called TRiC (yellow). The process starts when a ...

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a ...

Gram-negative bacteria that are resistant to multiple drugs cannot survive without the cell-surface machinery that builds a β-barrel pore structure from outer membrane proteins. Snapshots of different ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

An illustration showing how the nascent polypeptide-associated complex (NAC, green) at the ribosome (blue) helps the amino acid chain (white) to fold into a protein. In the earliest phase of creating ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins ...

In a study published in PNAS, a research team developed a new reinforcement learning-based enhanced sampling method called Adaptive Collective Variables Generator (Adaptive CVgen), which has been ...

During animal cell division, a highly synchronized and tightly regulated dance of chromosomes takes place, ensuring the chromosomes split correctly into the two cells. Spindle fibers—complex machinery ...