This image illustrates the chemical structure of a purine molecule, highlighting the numbering of the carbon and nitrogen atoms. The purine structure consists of a pyrimidine ring (positions 1 to 6) ...

Purines are nitrogenous bases that constitute fundamental building blocks of DNA and RNA. Through two primary routes—de novo synthesis and salvage pathways—cells maintain purine pools required for ...

Cell metabolism is often thought of as the process of breaking down sugars to create energy, but the process also involves all the biosynthetic reactions necessary to sustain life. One of these ...

Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in ...

A world-first discovery, published in the journal Science, rewrites our understanding of how cells control the production of DNA’s building blocks - and how this process affects the response to widely ...

Tsukuba, Japan—Microglia are resident immune cells in the central nervous system that participate in the regulation of brain homeostasis throughout life. In early postnatal stages, microglia regulate ...

Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.