The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

G protein-coupled receptor kinase 2 (GRK2) has emerged as a pivotal regulator in the pathophysiology of heart failure. GRK2 mediates the phosphorylation of activated G protein‐coupled receptors (GPCRs ...

The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns. Scientists at St. Jude Children's ...

Researchers at City St. George’s, University of London, have identified a new molecular signature that may explain why ...

Blossomhill Therapeutics Inc. has synthesized new indazole-based macrocyclic compounds acting as ALK tyrosine kinase receptor inhibitors potentially useful for the treatment of cancer.

Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a ...

Researchers have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a new study. The findings hold ...

Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice. Researchers at the NYU Pain Research Center have found a new receptor for ...