Schizophrenia and bipolar I disorder are two conditions that have many differences between them. A class of medicines called antipsychotics can be used to treat both conditions but may cause unwanted ...

The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) has announced it is assessing new data on the potential risk of neurodevelopmental disorders (NDDs) in ...

Other effective medicines are available for epilepsy and bipolar disorder and valproate should only be used if these don’t work or aren’t suitable for an individual patient. Image Credit: Medicines ...

High-dose valproate is associated with weight gain in psychiatric patients, with the greatest gain reported in those taking ≥ 1300 mg/d, new data showed. "These findings underscore the need for ...

Valproate-induced hyperammonemia is a serious but often under-recognised complication of valproic acid therapy, affecting patients receiving treatment for epilepsy, bipolar disorder and other ...

Paternal use of the anti-seizure medication valproate during spermatogenesis was not associated with a risk of congenital malformations or neurodevelopmental disorders in offspring, an observational ...

Maternal use of valproate during pregnancy has been associated with an increased risk of neurodevelopmental disorders in children. Although most studies of other antiseizure medications have not shown ...