Xanthine dehydrogenase (XDH), a rate-limiting enzyme involved in purine metabolism, has an essential role in inflammatory cascades. Researchers have known for decades that XDH activity is decreased in ...

IN 1954 Dent and Philpot 1 presented an account of xanthinuria observed in a four-year-old girl. She had only traces of uric acid in the blood and urine. Urinary excretion of purines consisted mainly ...

SWOG S0342 and S0536: Expression of EGFR protein and markers of epithelial-mesenchymal transformation (EMT) in cetuximab/chemotherapy-treated non-small cell lung cancer (NSCLC) ...

SINCE its clinical introduction in 1964, allopurinol (4-hydroxypyrazolo-[3,4-d]-pyrimidine) has been increasingly used for the treatment of hyperuricemia of gout, 1, 2 many neoplastic diseases and ...

Sekisui XenoTech has announced the addition of the H0606.S9(AX) Pooled Human Liver S9 and H0606.C(AX) Pooled Human Liver Cytosol test systems to the company’s catalog of in vitro drug development ...