G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

Previously unknown access points in cell membrane proteins have been discovered, enabling laboratory-developed drugs to modify cell function. The discovery was made possible through computer ...

Low-oxygen conditions ought to suffocate cells, but somehow cancer cells survive. They even progress and spread more aggressively, thanks to a newly identified signaling pathway, the HIF-GPRC5A-YAP ...

While investigating why cholesterol-lowering drugs called statins cause negative side effects such as blurred vision, short-term memory loss or increased risk for diabetes, cellular chemists at The ...

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

SEATTLE--(BUSINESS WIRE)--Omeros Corporation (Nasdaq: OMER) today announced a new approach to cancer immunotherapy that targets inhibition of GPR174, a member of the family of G protein-coupled ...

The β 2-adrenergic receptor (β 2-AR) is a typical G-proteincoupled receptor (GPCR) with rich pharmacology and has been targeted for treating various diseases such as asthma, chronic obstructive ...