Subtle cues between cells and immune system can contribute to spread of cancer

In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new ...
Purdue University

Subtle cues between cells and immune system contribute to spread of cancer

Purdue University scientists are deciphering an intricate cellular signaling system critical to immune response to better ...
Phys.org

Locusts bypass classical molecular pathway to process smells and pheromones, study reveals

Animals depend on their sense of smell to locate food, identify mates and evade danger. In mammals, olfactory perception typically relies on G protein–coupled receptor (GPCR) pathways. Insects, by ...
eLife

G protein-coupled receptor diversity and evolution in the closest living relatives of Metazoa

This important study fills a gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...
PNAS

A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors

G protein–coupled receptors (GPCRs) constitute a family of integral membrane proteins that are involved in numerous physiological and pathophysiological processes in the human body, and they continue ...
C&EN

Wnt/β-Catenin Signaling Pathway Targeting Androgenetic Alopecia: How Far Can We Go Beyond Minoxidil and Finasteride?

School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of ...
C&EN

A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The complement 3a receptor (C3aR) is a G-protein-coupled receptor (GPCR) involved in ...