A 34-year-old man was admitted to the hospital because of left ear pain with hearing loss and facial droop on the left side.

Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence ...

To access our most recent research and articles on Covid-19 and Covid-19 vaccines, please visit the NEJM Coronavirus (Covid-19) page. To realize the potential of recently developed Covid-19 ...

NEJM Weekly CME Activities — complete online activities tied to specific NEJM articles to earn one CME credit per each successfully completed activity. NEJM Interactive Medical Cases ...

A total of 14 million Medicare beneficiaries receive the Low-Income Subsidy (LIS), which reduces cost sharing in Medicare Part D. Losing the LIS may impede medication access and affect mortality.

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

We thank the patient and his family for their participation in this study; all the persons involved in the rapid manufacturing and evaluation of k-abe, including Kamila Wlodarczyk, Nicholas Tougas ...

A 29-year-old woman was admitted to the hospital because of sore throat and peritonsillar swelling and bleeding. Symptoms did not abate with antimicrobial therapy. A diagnosis was made. This case ...

In this open-label trial with a 2-by-4 factorial design, we randomly assigned children with HIV who had first-line treatment failure to receive second-line therapy with tenofovir alafenamide ...

In this editorial, the authors describe the foundations of an N-of-1 gene-editing study to treat an infant with a urea-cycle disorder. 2 Department of Chemistry and Biochemistry, University of ...

Narcolepsy type 1 is a disorder of hypersomnolence caused by a loss of orexin neurons, which results in low orexin levels in the brain. In this phase 2, randomized, placebo-controlled trial ...