Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

T lymphocytes are central components of the adaptive immune system, tasked with recognising and responding to a wide array of antigens. Their activation is initiated through the engagement of the T ...

A phase one study shows personalised T cell activation induced durable immune responses with manageable toxicity in patients with chronic lymphocytic leukaemia receiving targeted therapy.

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...

This figure shows primary T cells modified using two approaches. CAR receptors are introduced through targeted DNA insertion (top), while CRISPRoff mRNA and guide RNAs silence additional genes through ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...