The San Francisco 49ers recently lost superstar edge rusher Nick Bosa to a season-ending inury, which crushes the team's defense. With Bosa on the sidelines for

NFL Week 5 odds, picks, predictions, TV channel, streaming information for Thursday Night Football game between San Francisco 49ers, Los Angeles Rams.

Week 5 practice and media schedule ahead of matchup vs. Rams, featuring Kyle Shanahan and Robert Saleh press conferences.

49ers quarterback Brock Purdy had his toe injury flare up after Sunday's game. So, it came as no surprise that the team estimated him as a non-participant in Monday's practice. The 49ers, who did not practice Monday, play the Rams on Thursday night.

Find single game tickets to the Los Angeles Rams vs. San Francisco 49ers NFL Week 5 matchup on Thursday, October 2, 2025 at SoFi Stadium.

Coming off a thrilling comeback victory over the Colts, the Rams set their sights on their second home game in five days hosting the 49ers on Thursday Night Football at SoFi Stadium. Kickoff Thursday in Inglewood, Calif. is scheduled for 5:15 p.m. pacific time on Amazon Prime Video.

The Niners laundry list of injuries finally caught up with them this past weekend as Trevor Lawrence and the Jaguars handed Kyle Shanahan's squad their first loss. Jacksonville jumped out to a 17-6 lead at halftime and the 49ers really never threatened a comeback in the second half.

Head Coach Kyle Shanahan said that 49ers safety Malik Mustapha could be back practicing with the 49ers after Week 6.

The San Francisco 49ers have already played two games without $53 million quarterback Brock Purdy and this Thursday’s game against the Los Angeles Rams could be a third. As the 49ers attempt to win their third game in a row when Mac Jones as the starter,