Alabama has opened as a favorite against the Vanderbilt Commodores in Week 6. Here are the latest odds for the game.

Our early leans for Vanderbilt vs. Alabama believe the Tide are being overvalued based on the "revenge" angle following last year's head-to-head loss.

Alabama football will face the team that derailed its 2024 season on Saturday, when Vanderbilt visits Tuscaloosa.

For the second year in a row, Vanderbilt follows Georgia on the Alabama football schedule. Will UA pass the complacency test it failed in 2024?

The No. 11 Alabama Crimson Tide (3-1) face a fellow SEC foe when they host the No. 17 Vanderbilt Commodores (5-0) on Saturday, October 4, 2025 at Bryant-Denny Stadium. To find out who we pick to win this contest, see the rest of this column.

Diego Pavia will aim to stay perfect against SEC teams in the state of Alabama this week. He has yet to lose to Alabama or Auburn in his career.

One of Diego Pavia's biggest football influences, former Texas A&M star Johnny Manziel will be on the Vanderbilt sideline at Alabama on Oct. 4.

While Vanderbilt is the team that enters this week undefeated, the betting public believes Alabama deserves to be a strong favorite.

This article was originally published on www.si.com/college/vanderbilt as Vanderbilt Opens as Significant Underdog Against Alabama. NASHVILLE— Vanderbilt football is a 13.5-point underdog as it travels to Tuscaloosa to face Alabama.