p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression.

Apr 29, 2025 · The p53 protein, encoded by the TP53 gene, functions as a transcription factor regulating genes involved in cell cycle control, DNA repair, and apoptosis. Typically low under …

p53 protein is a tumor suppressor encoded by a gene whose disruption is associated with ∼50–55% of all human cancers. p53 protein acts as a checkpoint in the cell cycle and …

May 10, 2025 · most frequent in human cancers resulting in abnormal forms of the p53 protein. The TP53 gene encodes the p53 protein, a vital tumor suppressor central to the maintenance …

Jun 15, 2025 · At the heart of this defense is a protein known as p53, often called the “guardian of the genome.” This protein is a component of a pathway that responds to cellular stress, …

Sep 26, 2022 · The p53 protein is a tumor suppressor encoded by the TP53 gene and consists of 393 amino acids with four main functional domains. This protein responds to various cellular …

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and …