p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …

Dec 19, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

Apr 29, 2025 · Explore the p53 signaling pathway, its regulatory mechanisms, and its role in maintaining cellular integrity and response to stress.

p53 p53 is a tumor suppressor gene and is commonly mutated in several human cancers. In routine diagnostic surgical pathology, mutation status is assessed based on p53 expression by …

Sep 26, 2022 · The p53 protein is a tumor suppressor encoded by the TP53 gene and consists of 393 amino acids with four main functional domains. This protein responds to various cellular …

Mar 28, 2024 · The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated …

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and …