In cell biology, single-cell analysis and subcellular analysis[1] refer to the study of genomics, transcriptomics, proteomics, metabolomics, and cell–cell interactions at the level of an individual cell, …

The present special issue on single-cell analysis includes five review papers that introduce the latest advances in technology, application, and data analysis. Two of these reviews summarize new …

Jul 17, 2025 · The goal is to reach a point where analysis happens in real time, at the cellular level, no matter the application. Single-cell analysis is valuable when dealing with heterogeneity or small …

In developmental biology, single-cell analysis is used to trace cell lineages and map developmental trajectories, revealing how different tissues and organs form during embryonic development.

Jul 1, 2025 · Here, we present Open Problems, a living, extensive, community-guided platform including 12 current single-cell tasks that we envisage raising standards for the selection, evaluation and...

Single-cell analysis is defined as a method that reveals cell-to-cell variances within heterogeneous cell populations, providing critical cytological information and enabling more accurate statistical analysis …

By analyzing cells one at a time, researchers can detect meaningful differences in gene expression, protein levels, or DNA sequence that bulk methods would miss.

May 26, 2025 · Single-cell sequencing techniques have revolutionized the field of single-cell analysis, enabling researchers to study the genetic material of individual cells at high resolution. Some of the …

Jul 17, 2024 · For newcomers to the field of single-cell analysis as well as for experts, scientists led by Fabian Theis, Head of the Computational Health Center at Helmholtz Munich and Professor at the …

Mar 31, 2023 · Here, we summarize independent benchmarking studies of unimodal and multimodal single-cell analysis across modalities to suggest comprehensive best-practice workflows for the most …