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  1. Methyl Group - an overview | ScienceDirect Topics

    A methyl group is defined as a stable functional group consisting of a central carbon atom bonded to three hydrogen atoms. It is typically unreactive but can participate in methylation reactions …

  2. Methyl Group - an overview | ScienceDirect Topics

    A methyl group is defined as a functional group consisting of one carbon atom bonded to three hydrogen atoms (–CH₃), which exhibits unique motional characteristics, particularly in low …

  3. The Tiny but Marvelous Methyl Group in Insecticide Discovery: A ...

    Dec 12, 2025 · The methyl group, comprising a carbon atom bonded to three hydrogen atoms, is the most basic organic moiety. Despite its seemingly minor and easily overlooked appearance, …

  4. Methyl Group - an overview | ScienceDirect Topics

    The methyl group is the prototype of a saturated aliphatic substituent with lipophilic and electron-donor inductive effects. In some instances, it can advantageously be replaced by related …

  5. Methyl-containing pharmaceuticals: Methylation in drug design

    Nov 1, 2018 · Methyl is the smallest alkyl group, addition of a methyl group in a molecule makes only small changes in molecular weight and lipophilicity (ΔMW = 14 g/mol, Δ clog P ≈ 0.5), …

  6. The magic of a methyl group: Biochemistry at the service of …

    Oct 1, 2023 · A carbon–carbon linkage is created when a methyl group is implanted on dUMP, thus resulting in the formation of dTMP by thymidylate synthase. The methyl group is deleted …

  7. DNA Methylation - an overview | ScienceDirect Topics

    DNA methylation DNA methylation is the process during which a methyl group is added to a cytosine residue. How this epigenetic process contributes to transcriptional control depends on …

  8. S-Adenosylmethionine: more than just a methyl donor

    Protein crystallography has thus become a critical tool in understanding the details of SAM-dependent alkylation reactions. The following section is focused mainly on more recent …

  9. Mechanisms of human DNA methylation, alteration of methylation …

    Jul 30, 2023 · Methylation is a crucial DNA modification that has significant effects on gene expression. Among the various forms of DNA methylation, cytosine methylation is the most …

  10. DNA Methylation - an overview | ScienceDirect Topics

    DNA methylation is an epigenetic modification involving the transfer of a methyl group onto the C5 position of the cytosine ring of DNA to form 5-methylcytosine (5 mC), and regarded as an …