CFTR Modulator Therapies
CFTR Modulator Therapies
Aug 13, 2024
cff.org
Since 2012 when the first CFTR modulator, Kalydeco, was approved, modulator therapy has transformed cystic fibrosis care. By the end of 2024, 24,524 people with CF in the United States were prescribed Trikafta, according to data from the Patient Registry. However, 7.3% of people with CF were still not eligible for any CFTR modulators due to their age or genotype. For them, our work is not done. We are committed to finding a cure and advancing therapies for every person with CF. | Cystic Fibrosis
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Since 2012 when the first CFTR modulator, Kalydeco, was approv…
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Until recently, only about 60 percent of the cystic fibrosis population was eligible for CFTR modulator therapy. Now, with the approval of Trikafta, a triple-combination CFTR modulator therapy, more than 90 percent of people with CF could eventually have a highly effective therapy for the underlying cause of their disease. Alex Gifford, MD, an associate professor of medicine and the director of the adult CF program at Dartmouth-Hitchcock, discusses clinical trials that study the effects of CFTR
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